➦   Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

➦   TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

➦   Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

➦   Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

➦   Akt regulates growth by directly phosphorylating Tsc2

➦   Invasive cell migration is initiated by guided growth of long cellular extensions

➦   Microscopic analysis of polymerization dynamics with individual actin filaments

➦   Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

➦   Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

➦   Proteasome subunit Rpn1 binds ubiquitin-like protein domains

➦   Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

➦   Subnuclear shuttling of human telomerase induced by transformation and DNA damage

➦   The Semaphorin 4D receptor controls invasive growth by coupling with Met

➦   Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Droso

➦   MOR1/GEM1 has an essential role in the plant-specific cytokinetic phragmoplast

➦   Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 6

➦   Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes

➦   Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb

➦   Chemomechanical coupling of the forward and backward steps of single kinesin molecules

➦   Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis

➦   Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion

➦   Site of the previous meiotic division defines cleavage orientation in the mouse embryo

➦   De novo formation of transitional ER sites and Golgi structures in Pichia pastoris

➦   Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion b

➦   Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes

➦   Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

➦   Polyglutamine protein aggregates are dynamic

➦   One-Eyed Pinhead and Spadetail are essential for heart and somite formation

➦   Astral microtubules monitor metaphase spindle alignment in fission yeast

➦   Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa c

➦   CNS integrins switch growth factor signalling to promote target-dependent survival

➦   Direct coupling of the cell cycle and cell death machinery by E2F

➦   NF-κB2 p100 is a pro-apoptotic protein with anti-oncogenic function

➦   The Doc1 subunit is a processivity factor for the anaphase-promoting complex

➦   BID regulation by p53 contributes to chemosensitivity

➦   A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

➦   Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

➦   Membrane microviscosity regulates endothelial cell motility

➦   Wound healing recapitulates morphogenesis in Drosophila embryos

➦   ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disas

➦   PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

➦   Regulated exocytosis: a novel, widely expressed system

➦   Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP

➦   Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes

➦   Planar polarity and actin dynamics in the epidermis of Drosophila

➦   53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human can

➦   Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites

➦   The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

➦   Extraembryonic proteases regulate Nodal signalling during gastrulation

➦   UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis