➦   Spatial control of coated-pit dynamics in living cells

➦   Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

➦   Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 deg

➦   Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kin

➦   Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spr

➦   Endocytic vesicles move at the tips of actin tails in cultured mast cells

➦   Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

➦   Nucleolar Arf sequesters Mdm2 and activates p53

➦   High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism

➦   Strain-specific prion-protein conformation determined by metal ions

➦   Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos

➦   Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis

➦   SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

➦   Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

➦   Structure of the Janus-faced C2B domain of rabphilin

➦   Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane do

➦   Spatial control of actin polymerization during neutrophil chemotaxis

➦   Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

➦   Temporal and spatial control of cyclin B1 destruction in metaphase

➦   MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

➦   Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans

➦   Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

➦   Competition between glutathione and protein thiols for disulphide-bond formation

➦   Retinoic acid regulates programmed cell death through BMP signalling

➦   A new Drosophila APC homologue associated with adhesive zones of epithelial cells

➦   Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

➦   Noggin is a mesenchymally derived stimulator of hair-follicle induction

➦   Haem oxygenase-1 prevents cell death by regulating cellular iron

➦   Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein

➦   Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

➦   Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions

➦   Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule

➦   SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

➦   A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

➦   p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

➦   Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

➦   Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop

➦   Role for α-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies

➦   Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase

➦   The base of the proteasome regulatory particle exhibits chaperone-like activity

➦   Phosphatidylinositol-3-OH kinases are Rab5 effectors

➦   Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spread

➦   Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

➦   Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

➦   The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled recepto

➦   Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pa

➦   Kinesin’s tail domain is an inhibitory regulator of the motor domain

➦   ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Go

➦   The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast

➦   Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase