➦ Chk2 activates E2F-1 in response to DNA damage
➦ Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
➦ Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
➦ Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosi
➦ EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation
➦ The pathogenic peroxin Pex26p recruits the Pex1p–Pex6p AAA ATPase complexes to peroxisomes
➦ Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
➦ Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
➦ Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
➦ NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
➦ Proliferative lifespan is conserved after nuclear transfer
➦ Differential regulation of E2F1 apoptotic target genes in response to DNA damage
➦ Syntaxin specificity of cytokinesis in Arabidopsis
➦ MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb
➦ Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre
➦ Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
➦ Rheb promotes cell growth as a component of the insulin/TOR signalling network
➦ Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
➦ Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
➦ Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23
➦ Centrosome number is controlled by a centrosome-intrinsic block to reduplication
➦ Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
➦ Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential
➦ The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans
➦ Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
➦ Crosstalk between Rap1 and Rac regulates secretion of sAPPα
➦ Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization
➦ Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells
➦ Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of
➦ Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
➦ Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice
➦ Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in
➦ Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extra
➦ Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
➦ Cdk5 is essential for synaptic vesicle endocytosis
➦ Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs
➦ Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint
➦ Targeted movement of cell end factors in fission yeast
➦ A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter
➦ Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of h
➦ The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
➦ CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth
➦ Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic
➦ Activation of the interferon system by short-interfering RNAs
➦ Wingless promotes cell survival but constrains growth during Drosophila wing development
➦ Rac-dependent trans-endocytosis of ephrinBs regulates Eph–ephrin contact repulsion
➦ EphB–ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
➦ LKB1 (XEEK1) regulates Wnt signalling in vertebrate development
➦ Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP p
➦ The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila