➦   A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-c

➦   Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer the

➦   Targeted nanopore sequencing with Cas9-guided adapter ligation

➦   Massively parallel Cas13 screens reveal principles for guide RNA design

➦   Generation of human endothelium in pig embryos deficient in ETV2

➦   Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron

➦   Human chimeric antigen receptor macrophages for cancer immunotherapy

➦   High-throughput single-cell activity-based screening and sequencing of antibodies using droplet micr

➦   Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

➦   Morphing electronics enable neuromodulation in growing tissue

➦   CRISPR–Cas12-based detection of SARS-CoV-2

➦   Multiplex digital spatial profiling of proteins and RNA in fixed tissue

➦   Single-cell RNA counting at allele and isoform resolution using Smart-seq3

➦   Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic

➦   Targeted, efficient sequence insertion and replacement in rice

➦   Sequence-specific prediction of the efficiencies of adenine and cytosine base editors

➦   CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

➦   Glycosylase base editors enable C-to-A and C-to-G base changes

➦   Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics

➦   Detection of SARS-CoV-2 in nasal swabs using MALDI-MS

➦   A GRF–GIF chimeric protein improves the regeneration efficiency of transgenic plants

➦   Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

➦   Generation of paternal haploids in wheat by genome editing of the centromeric histone CENH3

➦   RNA timestamps identify the age of single molecules in RNA sequencing

➦   Fully phased human genome assembly without parental data using single-cell strand sequencing and lon

➦   Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2

➦   A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat

➦   Chromosome-scale, haplotype-resolved assembly of human genomes

➦   Noncanonical open reading frames encode functional proteins essential for cancer cell survival

➦   Improved metagenome binning and assembly using deep variational autoencoders

➦   Deep diversification of an AAV capsid protein by machine learning

➦   Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

➦   Modular, efficient and constant-memory single-cell RNA-seq preprocessing