➦   Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism
➦   Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding trans
➦   Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine de
➦   Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
➦   Genome-wide target specificities of CRISPR RNA-guided programmable deaminases
➦   Transplantation of engineered organoids enables rapid generation of metastatic mouse models of color
➦   In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
➦   Digital-to-biological converter for on-demand production of biologics
➦   Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly
➦   Guided self-organization and cortical plate formation in human brain organoids
➦   Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
➦   Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin recepto
➦   Engineered Cpf1 variants with altered PAM specificities
➦   A calcium- and light-gated switch to induce gene expression in activated neurons
➦   A light- and calcium-gated transcription factor for imaging and manipulating activated neurons
➦   Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer
➦   Haplotype phasing of whole human genomes using bead-based barcode partitioning in a single tube
➦   Cell-type-specific metabolic labeling of nascent proteomes in vivo
➦   Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
➦   Retrieval of a million high-quality, full-length microbial 16S and 18S rRNA gene sequences without p
➦   Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing ef
➦   A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
➦   A highly specific SpCas9 variant is identified by in vivo screening in yeast
➦   Engineered promoters enable constant gene expression at any copy number in bacteria
➦   IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival i
➦   Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
➦   Simultaneous lineage tracing and cell-type identification using CRISPR–Cas9-induced genetic scars
➦   High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas
➦   Secure genome-wide association analysis using multiparty computation
➦   Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryo
➦   Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular
➦   De novo DNA synthesis using polymerase-nucleotide conjugates
➦   Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylatio
➦   Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine de
➦   Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrange
➦   Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure
➦   An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
➦   Efficient proximity labeling in living cells and organisms with TurboID
➦   A universal SNP and small-indel variant caller using deep neural networks
➦   Genome editing of upstream open reading frames enables translational control in plants
➦   Optimized base editors enable efficient editing in cells, organoids and mice
➦   On-demand manufacturing of clinical-quality biopharmaceuticals
➦   Variation graph toolkit improves read mapping by representing genetic variation in the reference
➦   Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides
➦   Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells
➦   ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification
➦   Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice
➦   T cell receptor fingerprinting enables in-depth characterization of the interactions governing recog
➦   A massively parallel reporter assay dissects the influence of chromatin structure on cis-regulatory
➦   Clonal seeds from hybrid rice by simultaneous genome engineering of meiosis and fertilization genes