➦   Real-time measurement of protein–protein interactions at single-molecule resolution using a biologic
➦   Biofortification of field-grown cassava by engineering expression of an iron transporter and ferriti
➦   Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
➦   Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene,
➦   Resistance gene cloning from a wild crop relative by sequence capture and association genetics
➦   Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immuno
➦   Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like
➦   NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent
➦   Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution
➦   One-step genome editing of elite crop germplasm during haploid induction
➦   Genome-wide target specificity of CRISPR RNA-guided adenine base editors
➦   Specification of positional identity in forebrain organoids
➦   Precise gene replacement in rice by RNA transcript-templated homologous recombination
➦   Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
➦   Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria
➦   Simultaneous quantification of protein–DNA contacts and transcriptomes in single cells
➦   A coiled-coil masking domain for selective activation of therapeutic antibodies
➦   De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
➦   Spatial metagenomic characterization of microbial biogeography in the gut
➦   Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common an
➦   CRISPR DNA base editors with reduced RNA off-target and self-editing activities
➦   Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common an
➦   CRISPR DNA base editors with reduced RNA off-target and self-editing activities
➦   Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs
➦   Supercooling extends preservation time of human livers
➦   Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs
➦   Supercooling extends preservation time of human livers
➦   Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays
➦   Adenine base editors catalyze cytosine conversions in human cells
➦   Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays
➦   Adenine base editors catalyze cytosine conversions in human cells
➦   Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recru
➦   High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell
➦   Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recru
➦   High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell
➦   Harnessing type I CRISPR–Cas systems for genome engineering in human cells
➦   Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes
➦   Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia
➦   Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing
➦   A DNA-of-things storage architecture to create materials with embedded memory
➦   Large multiple sequence alignments with a root-to-leaf regressive method
➦   Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore
➦   Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficien
➦   Rapid customization of Solanaceae fruit crops for urban agriculture
➦   A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo
➦   An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance
➦   Accurate detection of mosaic variants in sequencing data without matched controls
➦   Identifying drug targets in tissues and whole blood with thermal-shift profiling
➦   Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors
➦   Complete, closed bacterial genomes from microbiomes using nanopore sequencing