➦   Real-time measurement of protein–protein interactions at single-molecule resolution using a biologic

➦   Biofortification of field-grown cassava by engineering expression of an iron transporter and ferriti

➦   Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides

➦   Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene,

➦   Resistance gene cloning from a wild crop relative by sequence capture and association genetics

➦   Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immuno

➦   Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like

➦   NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent

➦   Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution

➦   One-step genome editing of elite crop germplasm during haploid induction

➦   Genome-wide target specificity of CRISPR RNA-guided adenine base editors

➦   Specification of positional identity in forebrain organoids

➦   Precise gene replacement in rice by RNA transcript-templated homologous recombination

➦   Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

➦   Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria

➦   Simultaneous quantification of protein–DNA contacts and transcriptomes in single cells

➦   A coiled-coil masking domain for selective activation of therapeutic antibodies

➦   De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans

➦   Spatial metagenomic characterization of microbial biogeography in the gut

➦   Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common an

➦   CRISPR DNA base editors with reduced RNA off-target and self-editing activities

➦   Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common an

➦   CRISPR DNA base editors with reduced RNA off-target and self-editing activities

➦   Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs

➦   Supercooling extends preservation time of human livers

➦   Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs

➦   Supercooling extends preservation time of human livers

➦   Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays

➦   Adenine base editors catalyze cytosine conversions in human cells

➦   Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays

➦   Adenine base editors catalyze cytosine conversions in human cells

➦   Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recru

➦   High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

➦   Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recru

➦   High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

➦   Harnessing type I CRISPR–Cas systems for genome engineering in human cells

➦   Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes

➦   Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

➦   Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing

➦   A DNA-of-things storage architecture to create materials with embedded memory

➦   Large multiple sequence alignments with a root-to-leaf regressive method

➦   Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore

➦   Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficien

➦   Rapid customization of Solanaceae fruit crops for urban agriculture

➦   A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo

➦   An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

➦   Accurate detection of mosaic variants in sequencing data without matched controls

➦   Identifying drug targets in tissues and whole blood with thermal-shift profiling

➦   Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors

➦   Complete, closed bacterial genomes from microbiomes using nanopore sequencing