➦ Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
➦ Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
➦ S-phase checkpoint controls mitosis via an APC-independent Cdc20p function
➦ Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases
➦ Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by
➦ Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles
➦ Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis
➦ Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplan
➦ EB1 reveals mobile microtubule nucleation sites in Arabidopsis
➦ The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila
➦ Discs-Large and Strabismus are functionally linked to plasma membrane formation
➦ Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers
➦ Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint
➦ Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskele
➦ Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1
➦ Scaffold-mediated symmetry breaking by Cdc42p
➦ Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptos
➦ Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
➦ Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres
➦ RGS16 inhibits signalling through the Gα13–Rho axis
➦ Alternate fast and slow stepping of a heterodimeric kinesin molecule
➦ Mitochondrial translocation of cofilin is an early step in apoptosis induction
➦ A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility
➦ Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables
➦ Securin and B-cyclin/CDK are the only essential targets of the APC
➦ Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
➦ Polycomb CBX7 has a unifying role in cellular lifespan
➦ Late-G1 cyclin–CDK activity is essential for control of cell morphogenesis in budding yeast
➦ The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
➦ Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reti
➦ Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase path
➦ A novel mechanism for the store-operated calcium influx pathway
➦ An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans
➦ Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex
➦ ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway
➦ The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic
➦ FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
➦ The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex
➦ A physical and functional map of the human TNF-α/NF-κB signal transduction pathway
➦ Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2
➦ Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network
➦ Lipid raft proteins have a random distribution during localized activation of the T-cell receptor
➦ Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
➦ Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination
➦ Correcting improper chromosome–spindle attachments during cell division
➦ Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis
➦ MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence
➦ GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network
➦ Minimal nuclear pore complexes define FG repeat domains essential for transport