➦   Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

➦   Transduction peptides: from technology to physiology

➦   Kinetochore fibre dynamics outside the context of the spindle during anaphase

➦   A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human ce

➦   Dynamin 2 binds γ-tubulin and participates in centrosome cohesion

➦   Gating of CFTR by the STAS domain of SLC26 transporters

➦   SREBPs suppress IRS-2-mediated insulin signalling in the liver

➦   Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by

➦   PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

➦   Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity

➦   Abi1 is essential for the formation and activation of a WAVE2 signalling complex

➦   Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate

➦   Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

➦   Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

➦   Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane

➦   FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

➦   Golgi targeting of ARF-like GTPase Arl3p requires its Nα-acetylation and the integral membrane prote

➦   PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia

➦   Amplitude control of cell-cycle waves by nuclear import

➦   An epididymis-specific β-defensin is important for the initiation of sperm maturation

➦   In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the ear

➦   The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila

➦   Hematopoietic stem cells convert into liver cells within days without fusion

➦   Cohesin SMC1β is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombi

➦   Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

➦   Myosin-X provides a motor-based link between integrins and the cytoskeleton

➦   Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasi

➦   Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling

➦   Memo mediates ErbB2-driven cell motility

➦   HIF activation by pH-dependent nucleolar sequestration of VHL

➦   PTOP interacts with POT1 and regulates its localization to telomeres

➦   A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons

➦   PML regulates p53 stability by sequestering Mdm2 to the nucleolus

➦   Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activ

➦   Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiqui

➦   ATR and ATM regulate the timing of DNA replication origin firing

➦   LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

➦   Centriolar SAS-5 is required for centrosome duplication in C. elegans

➦   Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers act

➦   Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol

➦   SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

➦   Specification of a DNA replication origin by a transcription complex

➦   The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor

➦   Dicer is essential for formation of the heterochromatin structure in vertebrate cells

➦   The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans

➦   RGM and its receptor neogenin regulate neuronal survival

➦   Rapid vesicular translocation and insertion of TRP channels

➦   Neogenin mediates the action of repulsive guidance molecule

➦   The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements

➦   Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function