➦   Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

➦   Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell ster

➦   Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activ

➦   Basic mechanism of three-dimensional collagen fibre transport by fibroblasts

➦   FoxM1 is required for execution of the mitotic programme and chromosome stability

➦   SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells

➦   Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoie

➦   TRPC1 forms the stretch-activated cation channel in vertebrate cells

➦   OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

➦   JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic respons

➦   The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

➦   Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

➦   Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis

➦   Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during in

➦   c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

➦   c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

➦   Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size con

➦   Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for G

➦   Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

➦   PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1

➦   Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion

➦   Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

➦   Imaging of single light-responsive clock cells reveals fluctuating free-running periods

➦   Wnt signalling induces maturation of Paneth cells in intestinal crypts

➦   Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis

➦   Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

➦   Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dyn

➦   Prediction and validation of the distinct dynamics of transient and sustained ERK activation

➦   An α4 integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating ce

➦   SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions

➦   Regulation of PTEN by Rho small GTPases

➦   Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intrace

➦   CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instabi

➦   Actin and Arf1-dependent recruitment of a cortactin–dynamin complex to the Golgi regulates post-Golg

➦   Active intranuclear movement of herpesvirus capsids

➦   APC is a component of an organizing template for cortical microtubule networks

➦   EphrinB–EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of

➦   The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium

➦   Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

➦   Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophi

➦   Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle

➦   Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and

➦   Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primar

➦   Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor subst

➦   CtBP3/BARS drives membrane fission in dynamin-independent transport pathways

➦   Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

➦   Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit

➦   Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

➦   The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization

➦   The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia