➦ Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation
➦ Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism
➦ An aptamer-functionalized chemomechanically modulated biomolecule catch-and-release system
➦ Highly emissive platinum(II) metallacages
➦ Quantum dynamical resonances in low-energy CO(j = 0) + He inelastic collisions
➦ Prediction and accelerated laboratory discovery of previously unknown 18-electron ABX compounds
➦ Assembling molecular Sierpiński triangle fractals
➦ Two-stage directed self-assembly of a cyclic [3]catenane
➦ Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins
➦ Introducing structural sensitivity into adsorption–energy scaling relations by means of coordination
➦ A protonation-coupled feedback mechanism controls the signalling process in bathy phytochromes
➦ The colibactin warhead crosslinks DNA
➦ All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane
➦ A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the
➦ Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan
➦ Reversal of Hückel (anti)aromaticity in the lowest triplet states of hexaphyrins and spectroscopic e
➦ Stabilization of elusive silicon oxides
➦ Functionalization of cobalt porphyrin–phospholipid bilayers with his-tagged ligands and antigens
➦ Freeze–thaw cycles as drivers of complex ribozyme assembly
➦ An infinite chainmail of M6L6 metallacycles featuring multiple Borromean links
➦ Adsorption-induced auto-amplification of enantiomeric excess on an achiral surface
➦ A molecular shuttle that operates inside a metal–organic framework
➦ Selective, rapid and optically switchable regulation of protein function in live mammalian cells
➦ Applying green chemistry to the photochemical route to artemisinin
➦ Simulation-guided DNA probe design for consistently ultraspecific hybridization
➦ The critical role of phase-transfer catalysis in aprotic sodium oxygen batteries
➦ Roaming-mediated ultrafast isomerization of geminal tri-bromides in the gas and liquid phases
➦ An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum
➦ Through-space transfer of chiral information mediated by a plasmonic nanomaterial
➦ Triamidoamine uranium(IV)–arsenic complexes containing one-, two- and threefold U–As bonding interac
➦ Diels–Alderase-free, bis-pericyclic, [4+2] dimerization in the biosynthesis of (±)-paracaseolide A
➦ An eight-step gram-scale synthesis of (−)-jiadifenolide
➦ Chemoselective conversion of biologically sourced polyols into chiral synthons
➦ An oxazetidine amino acid for chemical protein synthesis by rapid, serine-forming ligations
➦ Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulation
➦ Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition
➦ Photoinduced reversible switching of porosity in molecular crystals based on star-shaped azobenzene
➦ Quantum interference between H + D2 quasiclassical reaction mechanisms
➦ Optimization of a whole-cell biocatalyst by employing genetically encoded product sensors inside nan
➦ On-surface generation and imaging of arynes by atomic force microscopy
➦ Light-controlled self-assembly of non-photoresponsive nanoparticles
➦ Synthesis of marmycin A and investigation into its cellular activity
➦ Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyke
➦ Sub-50-fs photoinduced spin crossover in [Fe(bpy)3]2+
➦ Organocatalytic removal of formaldehyde adducts from RNA and DNA bases
➦ Significantly shorter Fe–S bond in cytochrome P450-I is consistent with greater reactivity relative
➦ Ultrahigh-throughput exfoliation of graphite into pristine ‘single-layer’ graphene using microwaves
➦ Asymmetric assembly of aldose carbohydrates from formaldehyde and glycolaldehyde by tandem biocataly
➦ Improved performance and stability of perovskite solar cells by crystal crosslinking with alkylphosp