➦   Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging

➦   Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspas

➦   A transferable model for singlet-fission kinetics

➦   Mechanically triggered heterolytic unzipping of a low-ceiling-temperature polymer

➦   Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel–enz

➦   Functional carbon nanosheets prepared from hexayne amphiphile monolayers at room temperature

➦   Colloidal inverse bicontinuous cubic membranes of block copolymers with tunable surface functional g

➦   Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reac

➦   A two-coordinate boron cation featuring C–B+–C bonding

➦   The cytotoxicity of (−)-lomaiviticin A arises from induction of double-strand breaks in DNA

➦   Single-molecule analysis of chirality in a multicomponent reaction network

➦   Oxidation of ethane to ethanol by N2O in a metal–organic framework with coordinatively unsaturated i

➦   Incorporation of protein flexibility and conformational energy penalties in docking screens to impro

➦   Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitati

➦   Bulk protonic conductivity in a cephalopod structural protein

➦   Design and synthesis of the first triply twisted Möbius annulene

➦   Enantiospecific sp2–sp3 coupling of secondary and tertiary boronic esters

➦   Development of a minimal saponin vaccine adjuvant based on QS-21

➦   Discovery and introduction of a (3,18)-connected net as an ideal blueprint for the design of metal–o

➦   Directed assembly of optoelectronically active alkyl–π-conjugated molecules by adding n-alkanes or π

➦   Cooperative activation of cyclobutanones and olefins leads to bridged ring systems by a catalytic [4

➦   Direct observation of the collapse of the delocalized excess electron in water

➦   An organic thiyl radical catalyst for enantioselective cyclization

➦   The direct anti-Markovnikov addition of mineral acids to styrenes

➦   Vibronic coherence in oxygenic photosynthesis

➦   Observation of an all-boron fullerene

➦   Control of ultrafast molecular photodissociation by laser-field-induced potentials

➦   Mass-selected nanoparticles of PtxY as model catalysts for oxygen electroreduction

➦   A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-re

➦   Controlling epithelial sodium channels with light using photoswitchable amilorides

➦   Evolution of enzyme catalysts caged in biomimetic gel-shell beads

➦   Template-directed covalent conjugation of DNA to native antibodies, transferrin and other metal-bind

➦   Harnessing redox activity for the formation of uranium tris(imido) compounds

➦   Irreversible xenon insertion into a small-pore zeolite at moderate pressures and temperatures

➦   Synthesis of hydroxyphthioceranic acid using a traceless lithiation–borylation–protodeboronation str

➦   A nanoporous two-dimensional polymer by single-crystal-to-single-crystal photopolymerization

➦   Asymmetric triplex metallohelices with high and selective activity against cancer cells

➦   Gram-scale synthesis of two-dimensional polymer crystals and their structure analysis by X-ray diffr

➦   Triazolinediones enable ultrafast and reversible click chemistry for the design of dynamic polymer s

➦   A redox hydrogel protects hydrogenase from high-potential deactivation and oxygen damage

➦   High-performance Ag–Co alloy catalysts for electrochemical oxygen reduction

➦   Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells

➦   Electron transfer through rigid organic molecular wires enhanced by electronic and electron–vibratio

➦   Efficient discovery of bioactive scaffolds by activity-directed synthesis

➦   Chiral self-sorting and amplification in isotropic liquids of achiral molecules

➦   Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

➦   In situ X-ray snapshot analysis of transient molecular adsorption in a crystalline channel

➦   Low-energy spectrum of iron–sulfur clusters directly from many-particle quantum mechanics

➦   Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents

➦   Capturing snapshots of post-synthetic metallation chemistry in metal–organic frameworks