➦   Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl p

➦   Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function

➦   Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

➦   Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expressio

➦   Molecular basis of transdifferentiation of pancreas to liver

➦   The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

➦   αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

➦   Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos

➦   A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

➦   Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway

➦   RETRACTED ARTICLE: Binding to the transferrin receptor is required for endocytosis of HFE and regula

➦   The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants

➦   Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

➦   Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila

➦   A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo

➦   A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C.

➦   DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

➦   Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1

➦   FRAP reveals that mobility of oestrogen receptor-α is ligand- and proteasome-dependent

➦   Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation

➦   Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage

➦   Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymme

➦   DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

➦   Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor

➦   Multi-step control of spindle pole body duplication by cyclin-dependent kinase