Author: ["Sarit Larisch","Youngsuk Yi","Rona Lotan","Hedviga Kerner","Sarah Eimerl","W. Tony Parks","Yossi Gottfried","Stephanie Birkey Reffey","Mark P. de Caestecker","David Danielpour","Naomi Book-Melamed","Rina Timberg","Colin S. Duckett","Robert J. Lechleider","Hermann Steller","Joseph Orly","Seong-Jin Kim","Anita B. Roberts"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-β signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-β or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis. Cite this article
Larisch, S., Yi, Y., Lotan, R. et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol 2, 915–921 (2000). https://doi.org/10.1038/35046566 