Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling eve
Author: ["Erica M. Selva","Kyoungja Hong","Gyeong-Hun Baeg","Stephen M. Beverley","Salvatore J. Turco","Norbert Perrimon","Udo Häcker"]
Publication: Nature Cell Biology
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Abstract
The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide–sugar transporter that transfers UDP–glucuronic acid, UDP–N-acetylglucosamine and possibly UDP–xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.
Cite this article
Selva, E., Hong, K., Baeg, GH. et al. Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat Cell Biol 3, 809–815 (2001). https://doi.org/10.1038/ncb0901-809
