Author: ["Satoshi Goto","Misako Taniguchi","Masatoshi Muraoka","Hidenao Toyoda","Yukiko Sado","Masao Kawakita","Shigeo Hayashi"]
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Abstract
Glycosylation modifies protein activities in various biological processes. Here, we report the functions of a novel UDP–sugar transporter (UST74C, an alternative name for Fringe connection (Frc)) localized to the Golgi apparatus in cellular signalling of Drosophila. Mutants in the frc gene exhibit phenotypes resembling wingless and Notch mutants. Both Fringe-dependent and Fringe-independent Notch pathways are affected, and both glycosylation and proteolytic maturation of Notch are defective in mutant larvae. The results suggest that changes in nucleotide–sugar levels can differently affect Wingless and two distinct aspects of Notch signalling.Cite this article
Goto, S., Taniguchi, M., Muraoka, M. et al. UDP–sugar transporter implicated in glycosylation and processing of Notch. Nat Cell Biol 3, 816–822 (2001). https://doi.org/10.1038/ncb0901-816 