Author: ["John N. Simons","Thomas P. Leary","George J. Dawson","Tami J. Pilot-Matias","A. Scott Muerhoff","George G. Schlauder","Suresh M. Desai","Isa K. Mushahwar"]
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Abstract
Two viruses, GB virus A (GBV-A) and GB virus B (GBV-B), were recently identified in the GB hepatitis agent. Human sera containing antibodies that recognize GBV-A and/or GBV-B recombinant proteins were subjected to polymerase chain reaction studies with degenerate oligonucleotides capable of amplifying a segment of the putative helicase genes from GBV-A, GBV-B or hepatitis C virus. Novel sequences related to members of the Flaviviridae were identified in sera from 12 individuals including 4 individuals with hepatitis. The limited nucleotide sequence identity between GBV-A, GBV-B and HCV sequences suggests that a novel virus, tentatively named GB virus C, may be responsible for some cases of non-A, non-B, non-C, non-D, non-E hepatitis.Cite this article
Simons, J., Leary, T., Dawson, G. et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med 1, 564–569 (1995). https://doi.org/10.1038/nm0695-564 