A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

Abstract

Expression of the RIα subunit of cAMP-dependent protein kinase type I is enhanced in human cancer cell lines, in primary tumours, in cells after transformation and in cells upon stimulation of growth. We have investigated the effect of sequence-specific inhibition of RIα gene expression on in vivo tumour growth. We report that single injection RIα antisense treatment results in a reduction in RIα expression and inhibition of tumour growth. Tumour cells behaved like untransformed cells by making less protein kinase type I. The RIα antisense, which produces a biochemical imprint for growth control, requires infrequent dosing to halt neoplastic growth in vivo.

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Nesterova, M., Cho-Chung, Y. A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth. Nat Med 1, 528–533 (1995). https://doi.org/10.1038/nm0695-528

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