Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
Author: ["Chris Boshoff","Thomas F. Schulz","Margaret M. Kennedy","Andrew K. Graham","Cyril Fisher","Alero Thomas","J. O'D. McGee","Robin A. Weiss","John J. O'Leary"]
Publication: Nature Medicine
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Abstract
Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new human herpesvirus, KSHV/HHV-8, have been identified in both HIV-associated and classical KS. We sought to identify the target cell of this virus in KS tumour tissue. Using PCR in situ hybridization (PCR-ISH) we show that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells. These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions.
Cite this article
Boshoff, C., Schulz, T., Kennedy, M. et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1, 1274–1278 (1995). https://doi.org/10.1038/nm1295-1274
