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Abstract
Idiotypic determinants of the immunoglobuiin expressed on the surface of B–cell lymphomas are tumor–specific antigens (TSAs), which can be targeted by immunotherapy. Immunization with DNA constructs encoding the idiotype (Id) of a murine B–cell lymphoma induced specific anti–Id antibody responses and protected mice against tumor challenge. Use of DNA encoding an Id/GM–CSF (idiotype/granulocyte–macrophage colony–stimulating factor) fusion protein improved vaccine efficacy, and xenogeneic immunoglobuiin constant region determinants were required for immunogenicity. These results indicate that DNA may be a simple and efficacious means of inducing immune responses against a weak, otherwise unrecognized tumor antigen, provided that additional stimuli are included with the DNA.Cite this article
Syrengelas, A., Chen, T. & Levy, R. DNA immunization induces protective immunity against B–cell lymphoma. Nat Med 2, 1038–1041 (1996). https://doi.org/10.1038/nm0996-1038 