Targeting gene expression to hypoxic tumor cells
Author: ["Gabi U. Dachs","Adam V. Patterson","John D. Firth","Peter. J. Ratcliffe","K.M. Stuart Townsend","Ian. J. Stratford","Adrian L. Harris"]
Publication: Nature Medicine
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as celts in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.
Cite this article
Dachs, G., Patterson, A., Firth, J. et al. Targeting gene expression to hypoxic tumor cells. Nat Med 3, 515–520 (1997). https://doi.org/10.1038/nm0597-515
