Author: ["Nadine G. Pakker","Daan W. Notermans","Rob J. De Boer","Marijke T.L. Roos","Frank De Wolf","Andrew Hill","John M. Leonard","Sven A. Danner","Frank Miedema","Peter T.A. Schellekens"]
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Abstract
The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.Cite this article
Pakker, N., Notermans, D., De Boer, R. et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat Med 4, 208–214 (1998). https://doi.org/10.1038/nm0298-208 