Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
Author: Nadeem, Muhammad; Imran, Muhammad; Aslam Gondal, Tanweer; Imran, Ali; Shahbaz, Muhammad; Muhammad Amir, Rai; Wasim Sajid, Muhammad; Batool Qaisrani, Tahira; Atif, Muhammad; Hussain, Ghulam; Salehi, Bahare; Adrian Ostrander, Elise; Martorell, Miquel; Sharifi-Rad, Javad; C. Cho, William; Martins, Natália. 2019.
Publication: Applied Sciences 2019, Vol. 9, Page 3139
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Abstract
Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.
Cite this article
Nadeem M, Imran M, Aslam Gondal T, Imran A, Shahbaz M, Muhammad Amir R, Wasim Sajid M, Batool Qaisrani T, Atif M, Hussain G, Salehi B, Adrian Ostrander E, Martorell M, Sharifi-Rad J, C. Cho W, Martins N. Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review. Applied Sciences. 2019; 9(15):3139.https://doi.org/10.3390/app9153139
