Halogen bonds as orthogonal molecular interactions to hydrogen bonds
Author: ["Andrea Regier Voth","Patricia Khuu","Keita Oishi","P. Shing Ho"]
Publication: Nature Chemistry
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Halogen bonds (X-bonds) are shown to be geometrically perpendicular to and energetically independent of hydrogen bonds (H-bonds) that share a common carbonyl oxygen acceptor. This orthogonal relationship is accommodated by the in-plane and out-of-plane electronegative potentials of the oxygen, which are differentially populated by H- and X-bonds. Furthermore, the local conformation of a peptide helps to define the geometry of the H-bond and thus the oxygen surface that is accessible for X-bonding. These electrostatic and steric forces conspire to impose a strong preference for the orthogonal geometry of X- and H-bonds. Thus, the optimum geometry of an X-bond can be predicted from the pattern of H-bonds in a folded protein, enabling X-bonds to be introduced to improve ligand affinities without disrupting these structurally important interactions. This concept of orthogonal molecular interactions can be exploited for the rational design of halogenated ligands as inhibitors and drugs, and in biomolecular engineering. A survey of protein–ligand complexes shows that hydrogen bonds and halogen bonds that share a common oxygen-atom acceptor are often geometrically perpendicular to one another. Moreover, theoretical studies on small-molecule models of such systems predict that these two interactions are energetically independent.
Cite this article
Voth, A., Khuu, P., Oishi, K. et al. Halogen bonds as orthogonal molecular interactions to hydrogen bonds. Nature Chem 1, 74–79 (2009). https://doi.org/10.1038/nchem.112