Specific fluorogenic probes for ozone in biological and atmospheric samples
Author: ["Amanda L. Garner","Claudette M. St Croix","Bruce R. Pitt","George D. Leikauf","Shin Ando","Kazunori Koide"]
Publication: Nature Chemistry
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Abstract
Ozone exposure is a growing global health problem, especially in urban areas. While ozone in the stratosphere protects the earth from harmful ultraviolet light, tropospheric or ground-level ozone is toxic and can damage the respiratory tract. It has recently been shown that ozone may be produced endogenously in inflammation and antibacterial responses of the immune system; however, these results have sparked controversy owing to the use of a non-specific colorimetric probe. Here we report the synthesis of fluorescent molecular probes able to unambiguously detect ozone in both biological and atmospheric samples. Unlike other ozone-detection methods, in which interference from different reactive oxygen species is often a problem, these probes are ozone specific. Such probes will prove useful for the study of ozone in environmental science and biology, and so possibly provide some insight into the role of ozone in cells. In addition to environmental concerns about ozone, there is some debate regarding its role in biological systems. Researchers have now developed a fluorescent molecular probe that can selectively detect ozone — in preference to other reactive oxygen species — in both atmospheric and biological samples.
Cite this article
Garner, A., St Croix, C., Pitt, B. et al. Specific fluorogenic probes for ozone in biological and atmospheric samples. Nature Chem 1, 316–321 (2009). https://doi.org/10.1038/nchem.240
