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Abstract
The development of new means of activating molecules and bonds for chemical reactions is a fundamental objective for chemists. In this regard, visible-light photoredox catalysis has emerged as a powerful technique for chemoselective activation of chemical bonds under mild reaction conditions. Here, we report a visible-light-mediated photocatalytic alcohol activation, which we use to convert alcohols to the corresponding bromides and iodides in good yields, with exceptional functional group tolerance. In this fundamentally useful reaction, the design and operation of the process is simple, the reaction is highly efficient, and the formation of stoichiometric waste products is minimized. Visible light photoredox catalysis has emerged as a powerful technique for chemoselective activation of chemical bonds under mild reaction conditions. Here, visible-light-mediated conversion of alcohols to the corresponding bromides and iodides is described. The reaction proceeds in good yield with exceptional functional group tolerance, and minimizes the formation of stoichiometric waste.Cite this article
Dai, C., Narayanam, J. & Stephenson, C. Visible-light-mediated conversion of alcohols to halides. Nature Chem 3, 140–145 (2011). https://doi.org/10.1038/nchem.949 