Author: ["Alexey Kotlyarov","Armin Neininger","Carola Schubert","Rolf Eckert","Carmen Birchmeier","Hans-Dieter Volk","Matthias Gaestel"]
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Abstract
MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endotoxic shock. This is due to a reduction of ∼90 % in the production of tumor necrosis factor-α (TNF-α) and not to a change in signalling from the TNF receptor. The level and stability of TNF-α mRNA is not reduced and TNF-α secretion is not affected. We conclude that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-α at a post-transcriptional level. Cite this article
Kotlyarov, A., Neininger, A., Schubert, C. et al. MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis . Nat Cell Biol 1, 94–97 (1999). https://doi.org/10.1038/10061 