Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport
Author: ["Toshihide Kobayashi","Marie-Hélène Beuchat","Margaret Lindsay","Sonia Frias","Richard D. Palmiter","Hitoshi Sakuraba","Robert G. Parton","Jean Gruenberg"]
Publication: Nature Cell Biology
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Abstract
The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann–Pick type C (NPC), and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device. The results also suggest that similar endosomal defects accompany the anti-phospholipid syndrome and NPC.
Cite this article
Kobayashi, T., Beuchat, MH., Lindsay, M. et al. Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol 1, 113–118 (1999). https://doi.org/10.1038/10084
