Author: ["Kristin B. Hendricks","Bo Qing Wang","Elisabeth A. Schnieders","Jeremy Thorner"]
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Abstract
In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1’s catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.Cite this article
Hendricks, K., Qing Wang, B., Schnieders, E. et al. Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase . Nat Cell Biol 1, 234–241 (1999). https://doi.org/10.1038/12058 