Author: ["Paola M.C. Lembo","Eric Grazzini","Jack Cao","Douglas A. Hubatsch","Manon Pelletier","Cyrla Hoffert","Stephane St-Onge","Chantevy Pou","Jean Labrecque","Thierry Groblewski","Dajan O’Donnell","Kemal Payza","Sultan Ahmad","Philippe Walker"]
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Abstract
Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we identify MCH as the ligand for the orphan receptor SLC-1. The rat SLC-1 is activated by nanomolar concentrations of MCH and is coupled to the G protein Gαi/o. The pattern of SLC-1 messenger RNA expression coincides with the distribution of MCH-containing nerve terminals and is consistent with the known central effects of MCH. Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies. Cite this article
Lembo, P., Grazzini, E., Cao, J. et al. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat Cell Biol 1, 267–271 (1999). https://doi.org/10.1038/12978 