Author: ["Hui Feng","Weiwei Zhong","George Punkosdy","Subin Gu","Liang Zhou","Erin K. Seabolt","Edward T. Kipreos"]
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Abstract
The human cullin protein CUL-2 functions in a ubiquitin-ligase complex with the von Hippel–Lindau (VHL) tumour suppressor protein. Here we show that, in Caenorhabditis elegans, cul-2 is expressed in proliferating cells and is required at two distinct points in the cell cycle, the G1-to-S-phase transition and mitosis. cul-2 mutant germ cells undergo a G1-phase arrest that correlates with accumulation of CKI-1, a member of the CIP/KIP family of cyclin-dependent-kinase inhibitors. In cul-2 mutant embryos, mitotic chromosomes are unable to condense, leading to unequal DNA segregation, chromosome bridging and the formation of multiple nuclei.Cite this article
Feng, H., Zhong, W., Punkosdy, G. et al. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat Cell Biol 1, 486–492 (1999). https://doi.org/10.1038/70272 