Author: ["Xuri Li","Annica Pontén","Karin Aase","Linda Karlsson","Alexandra Abramsson","Marko Uutela","Gudrun Bäckström","Mats Hellström","Hans Boström","Hong Li","Philippe Soriano","Christer Betsholtz","Carl-Henrik Heldin","Kari Alitalo","Arne Östman","Ulf Eriksson"]
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Abstract
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF α-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.Cite this article
Li, X., Pontén, A., Aase, K. et al. PDGF-C is a new protease-activated ligand for the PDGF α-receptor . Nat Cell Biol 2, 302–309 (2000). https://doi.org/10.1038/35010579 