Intercellular communication mediated by the extracellular calcium-sensing receptor
Author: ["Aldebaran M. Hofer","Silvana Curci","Marc A. Doble","Edward M. Brown","David I. Soybel"]
Publication: Nature Cell Biology
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Abstract
Agonist-evoked, intracellular Ca2+-signalling events are associated with active extrusion of Ca2+ across the plasma membrane, implying a local increase in Ca2+ concentration ([Ca2+]) at the extracellular face of the cell. The possibility that these external [Ca2+] changes may have specific physiological functions has received little consideration in the past. Here we show that, at physiological ambient [Ca2+], Ca2+ mobilization in one cell produces an extracellular signal that can be detected in nearby cells expressing the extracellular Ca2+-sensing receptor (CaR), a cell-surface receptor for divalent cations with a widespread tissue distribution. The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours.
Cite this article
Hofer, A., Curci, S., Doble, M. et al. Intercellular communication mediated by the extracellular calcium-sensing receptor. Nat Cell Biol 2, 392–398 (2000). https://doi.org/10.1038/35017020
