Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B

Abstract

The retinoid–X receptor (RXR) regulates multiple hormonal pathways through heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR). The orphan nuclear receptor NGFI-B (also called Nur77) can heterodimerize with RXR. Here we show that nerve growth factor (NGF) induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the NGFI-B–RXR heterodimer complex out of the nucleus using nuclear export signals within NGFI-B. As a consequence of the redistribution of RXR, the transcriptional activity of RXR–RAR is reduced. NGFI-B-mediated nuclear export of receptors may serve as a mechanism for crosstalk between NGF and retinoid pathways.

Cite this article

Katagiri, Y., Takeda, K., Yu, ZX. et al. Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B. Nat Cell Biol 2, 435–440 (2000). https://doi.org/10.1038/35017072

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