Author: ["Christian J. Meyer","Francis J. Alenghat","Paul Rim","Jenny Hwai-Jen Fong","Ben Fabry","Donald E. Ingber"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
This study was carried out to discriminate between two alternative hypotheses as to how cells sense mechanical forces and transduce them into changes in gene transcription. Do cells sense mechanical signals through generalized membrane distortion1,2 or through specific transmembrane receptors, such as integrins3? Here we show that mechanical stresses applied to the cell surface alter the cyclic AMP signalling cascade and downstream gene transcription by modulating local release of signals generated by activated integrin receptors in a G-protein-dependent manner, whereas distortion of integrins in the absence of receptor occupancy has no effect.Cite this article
Meyer, C., Alenghat, F., Rim, P. et al. Mechanical control of cyclic AMP signalling and gene transcription through integrins. Nat Cell Biol 2, 666–668 (2000). https://doi.org/10.1038/35023621 