Author: ["Shuji Hinuma","Yasushi Shintani","Shoji Fukusumi","Norio Iijima","Yoshio Matsumoto","Masaki Hosoya","Ryo Fujii","Takuya Watanabe","Kuniko Kikuchi","Yasuko Terao","Takahiko Yano","Takanori Yamamoto","Yuji Kawamata","Yugo Habata","Mari Asada","Chieko Kitada","Tsutomu Kurokawa","Haruo Onda","Osamu Nishimura","Masaki Tanaka","Yasuhiko Ibata","Masahiko Fujino"]
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Abstract
Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1–3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.Cite this article
Hinuma, S., Shintani, Y., Fukusumi, S. et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2, 703–708 (2000). https://doi.org/10.1038/35036326 