The function of PML in p53-dependent apoptosis
Author: ["Ailan Guo","Paolo Salomoni","Jianyuan Luo","Alan Shih","Sue Zhong","Wei Gu","Pier Paolo Pandolfi"]
Publication: Nature Cell Biology
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Abstract
The PML gene of acute promyelocytic leukaemia (APL) encodes a growth- and tumour-suppresor protein that is essential for several apoptotic signals. The mechanisms by which PML exerts its pro-apoptotic function are still unknown. Here we show that PML acts as a transcriptional co-activator with p53. PML physically interacts with p53 both in vitro and in vivo and co-localizes with p53 in the PML nuclear body (PML-NB). The co-activatory role of PML depends on its ability to localize in the PML-NB. p53-dependent, DNA-damage-induced apoptosis, transcriptional activation by p53, the DNA-binding ability of p53, and the induction of p53 target genes such as Bax and p21 upon γ-irradiation are all impaired in PML−/− primary cells. These results define a new PML-dependent, p53-regulatory pathway for apoptosis and shed new light on the function of PML in tumour suppression.
Cite this article
Guo, A., Salomoni, P., Luo, J. et al. The function of PML in p53-dependent apoptosis. Nat Cell Biol 2, 730–736 (2000). https://doi.org/10.1038/35036365
