Author: ["Thomas S. Shimizu","Nicolas Le Novère","Matthew D. Levin","Andrew J. Beavil","Brian J. Sutton","Dennis Bray"]
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Abstract
Coliform bacteria detect chemical attractants by means of a membrane-associated cluster of receptors and signalling molecules. We have used recently determined molecular structures, in conjunction with plastic models generated by three-dimensional printer technology, to predict how the proteins of the complex are arranged in relation to the plasma membrane. The proposed structure is a regular two-dimensional lattice in which the cytoplasmic ends of chemotactic-receptor dimers are inserted into a hexagonal array of CheA and CheW molecules. This structure creates separate compartments for adaptation and downstream signalling, and indicates a possible basis for the spread of activity within the cluster.Cite this article
Shimizu, T., Le Novère, N., Levin, M. et al. Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nat Cell Biol 2, 792–796 (2000). https://doi.org/10.1038/35041030 