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Abstract
Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these processes are important in many cells, few factors that regulate spindle placement are known. Previous work has shown that GPB-1, the Gβ subunit of a heterotrimeric G protein, is required for orientation of early cell division axes in C. elegans embryos. Here we show that GOA-1 (a Gαo) and the related GPA-16 are the functionally redundant Gα subunits and that GPC-2 is the relevant Gγ subunit that is required for spindle orientation in the early embryo. We show that Gα and Gβγ are involved in controlling distinct microtubule-dependent processes. Gβγ is important in regulating migration of the centrosome around the nucleus and hence in orientating the mitotic spindle. Gα is required for asymmetric spindle positioning in the one-celled embryo.Cite this article
Gotta, M., Ahringer, J. Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos. Nat Cell Biol 3, 297–300 (2001). https://doi.org/10.1038/35060092 