Author: ["A. Upshall","A. A. Kumar","M. C. Bailey","M. D. Parker","M. A. Favreau","K. P. Lewison","M. L. Joseph","J. M. Maraganore","G. L. McKnight"]
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Abstract
Strains of the filamentous fungus Aspergillus nidulans transformed with a functional cDNA comprising the entire coding region of human tissue plasminogen activator (t-PA) secrete biologically active protein into the culture medium. Activity is inhibited by treatment with t-PA specific polyclonal antibodies. The protein is correctly processed at the amino terminus and is not excessively glycosylated.Cite this article
Upshall, A., Kumar, A., Bailey, M. et al. Secretion of Active Human Tissue Plasminogen Activator from the Filamentous Fungus Aspergillus Nidulans. Nat Biotechnol 5, 1301–1304 (1987). https://doi.org/10.1038/nbt1287-1301 