Author: ["Carton W. Chen","Hsiu-Fen Lin","Cynthia L. Kuo","Hsiu-Lan Tsai","Jane F. -Y. Tsai"]
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Abstract
Cephamycin C, a member of the 7-methoxycephalosporin family of β-lactam antibiotics, is widely produced among actinomycetes. A 29.3 kb DNA segment from Streptomyces cattleya NRRL8057 was cloned that directed cephamycin C production in a heterologous host, Streptomyces lividans 1326. Introduction of the gene cluster into another cephamycin C-producing Streptomyces increased the production of cephamycin C.Cite this article
Chen, C., Lin, HF., Kuo, C. et al. Cloning and Expression of a DNA Sequence Conferring Cephamycin C Production. Nat Biotechnol 6, 1222–1224 (1988). https://doi.org/10.1038/nbt1088-1222 