Author: ["A. J. Clark","H. Bessos","J. O. Bishop","P. Brown","S. Harris","R. Lathe","M. McClenaghan","C. Prowse","J. P. Simons","C. B. A. Whitelaw","I. Wilmut"]
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Abstract
Transgenic livestock may prove useful for the large scale production of valuable proteins. By targeting expression to the mammary gland these proteins could be harvested from milk. To this end, we have designed a hybrid gene to direct the synthesis of human anti-hemophilic factor IX to the mammary gland, and introduced it into sheep. Two transgenic ewes, each carrying about 10 copies of the foreign gene, have been analysed for expression. Both animals express human factor IX RNA in the mammary gland and secrete the corresponding protein into their milk.Cite this article
Clark, A., Bessos, H., Bishop, J. et al. Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep. Nat Biotechnol 7, 487–492 (1989). https://doi.org/10.1038/nbt0589-487 