γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis

Abstract

Despite the prevalence of γδ T cells in mucosae that are typically colonized by Candida albicans, little is known of the possible role of these cells in resistance to candidiasis. A sharp increase in the number of γδ T cells and macrophages following intraperitoneal inoculation of mice with C. albicans led us to examine the role of these cells in the immune response to C. albicans. We show that the γδT cells enhance macrophage nitric oxide (NO) production and anti-candida activity, in vitro. We also propose that the γδ T cells regulate macrophage function during candidiasis in vivo as well, because depletion of these cells abrogated inducible NO synthase expression in mucosae and enhanced murine susceptibility to candidiasis.

Cite this article

Jones-Carson, J., Vazquez-Torres, A., van der Heyde, H. et al. γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis. Nat Med 1, 552–557 (1995). https://doi.org/10.1038/nm0695-552

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