Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malign
Author: ["Debra Weinstat-Saslow","Maria J. Merino","Richard E. Manrow","Julia A. Lawrence","Ray F. Bluth","Karl D. Wittenbel","Jean F. Simpson","David L. Page","Patricia S. Steeg"]
Publication: Nature Medicine
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Abstract
The elucidation of molecular alterations that occur during human breast cancer progression may contribute to the development of preventative strategies. Using in situ hybridizations on a cohort of 94 biopsy lesions, quantitatively increased cyclin D mRNA expression levels were observed in only 18% of benign lesions, which confer no or slightly increased breast cancer risk, and 18% of premalignant atypical ductal hyperplasias, which confer a four to fivefold increase in breast cancer risk. The transition to carcinoma was accompanied by frequent cyclin D mRNA overexpression in 76% of low-grade ductal carcinomas in situ, 87% of higher grade comedo ductal carcinomas in situ and 83% of infiltrating ductal breast carcinomas. The data identify a molecular event that may separate benign and premalignant human breast lesions from any form of breast carcinoma.
Cite this article
Weinstat-Saslow, D., Merino, M., Manrow, R. et al. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nat Med 1, 1257–1260 (1995). https://doi.org/10.1038/nm1295-1257
