Author: ["Margaret F.C. Callan","Neil Steven","Pete Krausa","Jamie D.K. Wilson","Paul A.H. Moss","Geraldine M. Gillespie","John I. Bell","Alan B. Rickinson","Andrew J. McMichael"]
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Abstract
Primary infection with Epstein–Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, the nature of which has been controversial. We show that large monoclonal or oligoclonal populations of CD8+ T cells account for a significant proportion of the lymphocytosis and provide molecular evidence that these populations have been driven by antigen. The results suggest that the selective and massive expansion of a few dominant clones of CD8+ T cells is an important feature of the primary response to this virus.Cite this article
Callan, M., Steven, N., Krausa, P. et al. Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nat Med 2, 906–911 (1996). https://doi.org/10.1038/nm0896-906 