Combined chemokine and cytokine gene transfer enhances antitumor immunity
Author: ["Dagmar Dilloo","Kevin Bacon","William Holden","Wanyun Zhong","Stefan Burdach","Albert Zlotnik","Malcolm Brenner"]
Publication: Nature Medicine
CITE.CC academic search helps you expand the influence of your papers.
Abstract
The probability of producing a specific antitumor response should be increased by multiplying the number of T lymphocytes that encounter the malignant cells. We tested this prediction in a murine model, using a recently discovered T–cell chemokine, lymphotactin (Lptn). This chemokine increased tumor cell infiltration with CD4+ lymphocytes but generated little antitumor activity. Coexpression of the T–cell growth factor interleukin–2, however, greatly expanded the T lymphocytes attracted by Lptn, affording protection from the growth of established tumor in a CD4+ and CD8+ T cell–dependent manner. Lesser synergy was seen with GM–CSF. Hence coexpression of a T–cell chemokine and T–cell growth factor potentiates antitumor responses in vivo, suggesting a general strategy to improve cancer immunotherapy.
Cite this article
Dilloo, D., Bacon, K., Holden, W. et al. Combined chemokine and cytokine gene transfer enhances antitumor immunity. Nat Med 2, 1090–1095 (1996). https://doi.org/10.1038/nm1096-1090
