Author: ["Ronit Sarid","Takaaki Sato","Roy A. Bohenzky","James J. Russo","Yuan Chang"]
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Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi's sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effusion lymphomas. Using yeast and human cells we demonstrate the ability of KSHV vBcl-2 protein to suppress Bax toxicity. We show that KSHV vBcl-2 heterodimerizes with human Bcl-2 in a yeast two-hybrid system. These results suggest that KSHV vBcl-2 plays an anti-apoptotic role in virus infected cells.Cite this article
Sarid, R., Sato, T., Bohenzky, R. et al. Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue. Nat Med 3, 293–298 (1997). https://doi.org/10.1038/nm0397-293 