Author: ["Mark Connors","Joseph A. Kovacs","Seth Krevat","Juan C. Gea-Banacloche","Michael C. Sneller","Mark Flanigan","Julia A. Metcalf","Robert E. Walker","Judith Falloon","Michael Baseler","Randy Stevens","Irwin Feuerstein","Henry Masur","H. Clifford Lane"]
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Abstract
Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4+ T cells was noted as disease progressed. Following protease inhibitor therapy, naive CD4+ T cells increased only if they were present before initiation of therapy. Disruptions of the CD4+ TCR repertoire were most prevalent in patients with the lowest CD4+ T-cell counts. Antiviral or IL-12 therapy-induced increases in CD4+ T-cell counts led to only minor changes in previously disrupted repertoires. Thus, CD4+ T-cell death mediated by HIV-1 infection may result in a preferential decline in the number of naive CD4+ T cells and disruptions of the CD4+T-cell repertoire that are not immediately corrected by antiviral or immune-based therapies.Cite this article
Connors, M., Kovacs, J., Krevat, S. et al. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat Med 3, 533–540 (1997). https://doi.org/10.1038/nm0597-533 