Author: ["Michael D. Lubeck","Robert Natuk","Maria Myagkikh","Narender Kalyan","Kristine Aldrich","Faruk Sinangil","Shabnam Alipanah","Shri C.S. Murthy","Pranab K. Chanda","Stephen M. Nigida Jr.","Phillip D. Markham","Susan Zolla-pazner","Kathy Steimer","Mark Wade","Marvin S. Reitz Jr.","Larry O. Arthur","Satoshi Mizutani","Alan Davis","Paul P. Hung","Robert C. Gallo","Jorg Eichberg","Marjorie Robert-Guroff"]
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Abstract
A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MNgp160 recom-binants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to low-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans.Cite this article
Lubeck, M., Natuk, R., Myagkikh, M. et al. Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization. Nat Med 3, 651–658 (1997). https://doi.org/10.1038/nm0697-651 