Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
Author: ["Mark Roman","Elena Martin-Orozco","Justin S. Goodman","Minh-Duc Nguyen","Yukio Sato","Arash Ronaghy","Richard S. Kornbluth","Douglas D. Richman","Dennis A. Carson","Eyal Raz"]
Publication: Nature Medicine
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Abstract
An adjuvant role for certain short bacterial immunostimulatory DNA sequences (ISSs) has recently been proposed on the basis of their ability to stimulate T helper-1 (Thl) responses in gene-vaccinated animals. We report here that noncoding, ISS-enriched plasmid DMAs or ISS oligonucleotides (ISS-ODNs) potently stimulate immune responses to coadministered antigens. The ISS-DNAs suppress IgE synthesis, but promote IgC and interferon-γ (IFN-γ) production. They furthermore initiate the production of IFN-γ, IFN-α, IFN-β, and interleukins 12 and 18, all of which foster Thl responses and enhance cell-mediated immunity. Consideration should be given to adding noncoding DNA adjuvants to inactivated or subunit viral vaccines that, by themselves, provide only partial protection from infection.
Cite this article
Roman, M., Martin-Orozco, E., Goodman, J. et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 3, 849–854 (1997). https://doi.org/10.1038/nm0897-849
