Author: ["Sandra Mazzoli","Daria Trabaironi","Sergio Lo Caputo","Stefania Piconi","Claudio Blé","Francesca Meacci","Stefania Ruzzante","Alessanda Salvi","Francesca Semplici","Renato Longhi","Maria Luisa Fusi","Nadia Tofani","Mara Biasin","Maria Luisa Villa","Francesco Mazzotta","Mario Clerici"]
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Abstract
HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were observed in their HIV-seropositive partners; antibodies were not detected in low-risk controls. Envelope protein (Env) peptide-stimulated interleukin-2 (IL-2) production by peripheral blood mononuclear cells (PBMCs) was detected in 9 out of 16 ESNs, 5 out of 16 HIV-infected patients and 1 out of 50 controls. Env peptide-stimulated PBMCs of ESNs produced more IL-2 and less IL-10 compared with those of HIV-infected individuals; no differences were observed in chemokine production or in CCR5 expression. These data demonstrate that a compartmentalized immune response to pathogens is possible in humans and raise the possibility of protective roles for cell-mediated immunity and mucosal IgA in HIV-seronegative individuals exposed to HIV.Cite this article
Mazzoli, S., Trabaironi, D., Caputo, S. et al. HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. Nat Med 3, 1250–1257 (1997). https://doi.org/10.1038/nm1197-1250 